Gustation genetics: sweet gustducin!
نویسندگان
چکیده
Two recent studies, the second of which is reported herein, provide evidence that genetic variation in the sweet receptor subunit, TAS1R3, and the second messenger, gustducin (GNAT3), affect the ability of people to correctly sort ascending concentrations of sucrose. These findings raise questions about how variation in the TAS1R3 and GNAT3 gene shape the human sweet tooth and its unwelcome consequences, diabetes and obesity.
منابع مشابه
Expression of gustducin overlaps with that of type III IP3 receptor in taste buds of the rat soft palate.
Type III IP3 receptor (IP3R3) is one of the common critical calcium-signaling molecules for sweet, umami, and bitter signal transduction in taste cells, and the total IP3R3-expressing cell population represents all cells mediating these taste modalities in the taste buds. Although gustducin, a taste cell-specific G-protein, is also involved in sweet, umami, and bitter signal transduction, the e...
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The G-protein subunit alpha-gustducin, which is similar to rod transducin, has been implicated in the transduction of both sweet- and bitter-tasting substances. In rodents, there are differences in sensitivity to sweet and bitter stimuli in different populations of taste buds. Rat fungiform taste buds are more responsive to salts than to sweet stimuli, whereas those on the palate respond predom...
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Glucagon-like peptide-1 (GLP-1), released from gut endocrine L cells in response to glucose, regulates appetite, insulin secretion, and gut motility. How glucose given orally, but not systemically, induces GLP-1 secretion is unknown. We show that human duodenal L cells express sweet taste receptors, the taste G protein gustducin, and several other taste transduction elements. Mouse intestinal L...
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We have demonstrated that an 8.4 kb segment (GUS(8.4)) from the upstream region of the mouse alpha-gustducin gene acts as a fully functional promoter to target lacZ transgene expression to the gustducin-positive subset of taste receptor cells (TRCs). The GUS(8. 4) promoter drove TRC expression of the beta-galactosidase marker at high levels and in a developmentally appropriate pattern. The gust...
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عنوان ژورنال:
- Chemical senses
دوره 35 7 شماره
صفحات -
تاریخ انتشار 2010